Proteins/UNIPROT:Q96PH6

DEFB118

ProteinUNIPROT:Q96PH6

Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis. Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes. Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface. Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization. May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms..

Function from UniProtKB (Q96PH6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 3 reference databases · Subject: DEFB118 · Sources: gene ontology, Hetionet, Reactome

Order

DEFB118 covaries with ATPAF2ProteinHetionet hetionet:covaries:117285-91647Inferred only
DEFB118 participates in Antimicrobial peptidesPathwayReactome R-HSA-6803157Inferred only
DEFB118 participates in Beta defensinsPathwayReactome R-HSA-1461957Inferred only
DEFB118 participates in DefensinsPathwayReactome R-HSA-1461973Inferred only
DEFB118 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
DEFB118 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
DEFB118 regulates negative regulation of cell adhesionBiological processgene ontology Q96PH6|GO:0007162Inferred only
DEFB118 regulates negative regulation of lipopolysaccharide-mediated signaling pathwayBiological processgene ontology Q96PH6|GO:0031665Inferred only

Other names

7 names

Resolves to: DEFB118

Also called: Beta-defensin 18C20orf63DEFB-18DEFB18Epididymal secretory protein 13.6ESC42ESP13.6

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