Proteins/UNIPROT:Q96JK2

DCAF5

ProteinUNIPROT:Q96JK2

Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1..

Function from UniProtKB (Q96JK2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 3 reference databases · Subject: DCAF5 · Sources: gene ontology, Hetionet, Reactome

Order

CUL4A interacts with DCAF5ProteinHetionet hetionet:interacts:8451-8816Inferred only
DDB1 interacts with DCAF5ProteinHetionet hetionet:interacts:1642-8816Inferred only
GRK5 interacts with DCAF5ProteinHetionet hetionet:interacts:2869-8816Inferred only
UBC interacts with DCAF5ProteinHetionet hetionet:interacts:7316-8816Inferred only
DCAF5 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
DCAF5 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
DCAF5 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
DCAF5 regulates regulation of stem cell population maintenanceBiological processgene ontology Q96JK2|GO:2000036Inferred only

Other names

6 names

Resolves to: DCAF5

Also called: BCRG2BCRP2Breakpoint cluster region protein 2KIAA1824WD repeat-containing protein 22WDR22

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