Proteins/UNIPROT:Q9H2A7

CXCL16

ProteinUNIPROT:Q9H2A7

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo..

Function from UniProtKB (Q9H2A7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 4 reference databases · Subject: CXCL16 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

SCIMP covaries with CXCL16ProteinHetionet hetionet:covaries:388325-58191Inferred only
CXCR6 interacts with CXCL16ProteinHetionet hetionet:interacts:10663-58191Inferred only
CXCL16 participates in Chemokine receptors bind chemokinesPathwayReactome R-HSA-380108Inferred only
CXCL16 participates in Chemokine signalingPathwayWikiPathways WP3929Inferred only
CXCL16 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
CXCL16 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
CXCL16 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
CXCL16 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
CXCL16 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
CXCL16 participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
CXCL16 participates in Overview of proinflammatory and profibrotic mediatorsPathwayWikiPathways WP5095Inferred only
CXCL16 participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only

Show the remaining 5

CXCL16 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CXCL16 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
CXCL16 participates in TYROBP causal network in microgliaPathwayWikiPathways WP3945Inferred only
CXCL16 regulates positive regulation of cell growthBiological processgene ontology Q9H2A7|GO:0030307Inferred only
CXCL16 regulates positive regulation of cell migrationBiological processgene ontology Q9H2A7|GO:0030335Inferred only

Other names

6 names

Resolves to: CXCL16

Also called: Scavenger receptor for phosphatidylserine and oxidized low density lipoproteinSCYB16Small-inducible cytokine B16SR-PSOXSRPSOXTransmembrane chemokine CXCL16

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