Proteins/UNIPROT:Q2VPK5

CTU2

ProteinUNIPROT:Q2VPK5

Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position..

Function from UniProtKB (Q2VPK5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

microcephaly, facial dysmorphism, renal agenesis, and ambiguous genitalia syndrome has a germline basis in CTU2DiseaseGenCC HGNC:28005|MONDO:0020647Inferred only

Statements

7 statements

7 statements · 2 reference databases · Subject: CTU2 · Sources: Hetionet, Reactome

Order

CTU2 covaries with CCDC185ProteinHetionet hetionet:covaries:164127-348180Inferred only
CTU1 interacts with CTU2ProteinHetionet hetionet:interacts:348180-90353Inferred only
MMS19 interacts with CTU2ProteinHetionet hetionet:interacts:348180-64210Inferred only
UBC interacts with CTU2ProteinHetionet hetionet:interacts:348180-7316Inferred only
CTU2 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
CTU2 participates in tRNA modification in the nucleus and cytosolPathwayReactome R-HSA-6782315Inferred only
CTU2 participates in tRNA processingPathwayReactome R-HSA-72306Inferred only

Other names

4 names

Resolves to: CTU2

Also called: C16orf84Cytoplasmic tRNA 2-thiolation protein 2Cytosolic thiouridylase subunit 2NCS2

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