CTF1

Functions as a cytokine that binds to the LIF receptor complex. The LIF receptor complex indeed consists of two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (By similarity). Functionally, acts as a potent cardiac survival factor, and promotes cardiomyocyte proliferation and hypertrophy. Mechanistically, ligand binding to LIFR, induces heterodimerization with IL6ST/gp130 activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains (By similarity). These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (By similarity). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activator of transcription STAT3 (By similarity)..

Function from UniProtKB (Q16619), read 2026-09-23. CC BY 4.0.