Proteins/UNIPROT:Q9NZV1

CRIM1

ProteinUNIPROT:Q9NZV1

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface..

Function from UniProtKB (Q9NZV1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

colobomatous macrophthalmia-microcornea syndrome has a germline basis in CRIM1DiseaseGenCC HGNC:2359|MONDO:0011239Inferred only

Statements

11 statements

11 statements · 3 reference databases · Subject: CRIM1 · Sources: gene ontology, Hetionet, WikiPathways

Order

CRIM1 covaries with CA11ProteinHetionet hetionet:covaries:51232-770Inferred only
ATXN7 interacts with CRIM1ProteinHetionet hetionet:interacts:51232-6314Inferred only
CACNA1A interacts with CRIM1ProteinHetionet hetionet:interacts:51232-773Inferred only
UBC interacts with CRIM1ProteinHetionet hetionet:interacts:51232-7316Inferred only
CRIM1 participates in Development of ureteric derived collecting systemPathwayWikiPathways WP5053Inferred only
CRIM1 regulates negative regulation of BMP signaling pathwayBiological processgene ontology Q9NZV1|GO:0030514Inferred only
CRIM1 regulates negative regulation of osteoblast differentiationBiological processgene ontology Q9NZV1|GO:0045668Inferred only
AKR1A1 increases the expression of CRIM1ProteinHetionet hetionet:regulates:10327-51232Inferred only
BPHL increases the expression of CRIM1ProteinHetionet hetionet:regulates:670-51232Inferred only
KHDRBS1 decreases the expression of CRIM1ProteinHetionet hetionet:regulates:10657-51232Inferred only
PRKCZ decreases the expression of CRIM1ProteinHetionet hetionet:regulates:5590-51232Inferred only

Other names

4 names

Resolves to: CRIM1

Also called: [Cleaved into: Processed cysteine-rich motor neuron 1 protein]CRIM-1Cysteine-rich repeat-containing protein S52S52

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