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Proteins/UNIPROT:Q8IUR6

CREBRF

Protein·UNIPROT:Q8IUR6

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Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci..

Function from UniProtKB (Q8IUR6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

11 statements

11 statements · 3 reference databases · Subject: CREBRF · Sources: gene ontology, Hetionet, Reactome

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CREBRF covaries with ZNF699ProteinHetionet hetionet:covaries:153222-374879Inferred only
CREB3 interacts with CREBRFProteinHetionet hetionet:interacts:10488-153222Inferred only
CREBRF participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
CREBRF participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
CREBRF participates in CREB3 factors activate genesPathwayReactome R-HSA-8874211Inferred only
CREBRF participates in Unfolded Protein Response (UPR)PathwayReactome R-HSA-381119Inferred only
CREBRF regulates negative regulation of endoplasmic reticulum unfolded protein responseBiological processgene ontology Q8IUR6|GO:1900102Inferred only
CREBRF regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q8IUR6|GO:0000122Inferred only
CREBRF regulates positive regulation of protein catabolic processBiological processgene ontology Q8IUR6|GO:0045732Inferred only
CREBRF regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q8IUR6|GO:0045944Inferred only
CREBRF regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q8IUR6|GO:0006357Inferred only

Other names

3 names

Resolves to: CREBRF

Also called: C5orf41LRFLuman recruitment factor

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