Proteins/UNIPROT:Q7Z4G1

COMMD6

ProteinUNIPROT:Q7Z4G1

Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation..

Function from UniProtKB (Q7Z4G1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

7 statements

7 statements · 3 reference databases · Subject: COMMD6 · Sources: gene ontology, Hetionet, Reactome

Order

COMMD1 interacts with COMMD6ProteinHetionet hetionet:interacts:150684-170622Inferred only
UBC interacts with COMMD6ProteinHetionet hetionet:interacts:170622-7316Inferred only
VCP interacts with COMMD6ProteinHetionet hetionet:interacts:170622-7415Inferred only
COMMD6 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
COMMD6 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
COMMD6 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
COMMD6 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q7Z4G1|GO:0000122Inferred only

Other names

1 name

Resolves to: COMMD6

Also called: COMM domain-containing protein 6

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