Proteins/UNIPROT:Q9GZQ3

COMMD5

ProteinUNIPROT:Q9GZQ3

Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation (By similarity). Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway (By similarity). Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B..

Function from UniProtKB (Q9GZQ3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

5 statements

5 statements · 2 reference databases · Subject: COMMD5 · Sources: Hetionet, Reactome

Order

COMMD5 interacts with COMMD1ProteinHetionet hetionet:interacts:150684-28991Inferred only
UBC interacts with COMMD5ProteinHetionet hetionet:interacts:28991-7316Inferred only
COMMD5 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
COMMD5 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
COMMD5 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Other names

2 names

Resolves to: COMMD5

Also called: HCaRGHypertension-related calcium-regulated gene protein

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