Proteins/UNIPROT:Q9UBI1

COMMD3

ProteinUNIPROT:Q9UBI1

Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits..

Function from UniProtKB (Q9UBI1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 2 reference databases · Subject: COMMD3 · Sources: Hetionet, Reactome

Order

COMMD3 interacts with COMMD1ProteinHetionet hetionet:interacts:150684-23412Inferred only
COMMD3 interacts with COMMD8ProteinHetionet hetionet:interacts:23412-54951Inferred only
TRAF5 interacts with COMMD3ProteinHetionet hetionet:interacts:23412-7188Inferred only
UBC interacts with COMMD3ProteinHetionet hetionet:interacts:23412-7316Inferred only
COMMD3 interacts with ZNF337ProteinHetionet hetionet:interacts:23412-26152Inferred only
COMMD3 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
COMMD3 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
COMMD3 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
COMMD3 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
COMMD3 participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
COMMD3 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
CXCL1 decreases the expression of COMMD3ProteinHetionet hetionet:regulates:2919-23412Inferred only

Show the remaining 2

RPP38 decreases the expression of COMMD3ProteinHetionet hetionet:regulates:10557-23412Inferred only
TGDS decreases the expression of COMMD3ProteinHetionet hetionet:regulates:23483-23412Inferred only

Other names

5 names

Resolves to: COMMD3

Also called: BUPC10orf8PILProtein BupProtein PIL

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