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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q9GZY4

COA1

Protein·UNIPROT:Q9GZY4

Open in the graph

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV. As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I..

Function from UniProtKB (Q9GZY4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

8 statements

8 statements · 3 reference databases · Subject: COA1 · Sources: Hetionet, Reactome, WikiPathways

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COPS6 interacts with COA1ProteinHetionet hetionet:interacts:10980-55744Inferred only
UBC interacts with COA1ProteinHetionet hetionet:interacts:55744-7316Inferred only
COA1 participates in Aerobic respiration and respiratory electron transportPathwayReactome R-HSA-1428517Inferred only
COA1 participates in Complex I biogenesisPathwayReactome R-HSA-6799198Inferred only
COA1 participates in Complex IV assemblyPathwayReactome R-HSA-9864848Inferred only
COA1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
COA1 participates in Mitochondrial complex I assembly model OXPHOS systemPathwayWikiPathways WP4324Inferred only
COA1 participates in Respiratory electron transportPathwayReactome R-HSA-611105Inferred only

Other names

4 names

Resolves to: COA1

Also called: C7orf44Cytochrome c oxidase assembly factor 1 homologMitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDaMITRAC15

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