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Reference

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Reactions
Reach

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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q8IZR5

CMTM4

Protein·UNIPROT:Q8IZR5

Open in the graph

Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation..

Function from UniProtKB (Q8IZR5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

3 statements

3 statements · 1 reference database · Subject: CMTM4 · Sources: Hetionet

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CTBP1 covaries with CMTM4ProteinHetionet hetionet:covaries:146223-1487Inferred only
APPL1 interacts with CMTM4ProteinHetionet hetionet:interacts:146223-26060Inferred only
MRPL2 interacts with CMTM4ProteinHetionet hetionet:interacts:146223-51069Inferred only

Other names

3 names

Resolves to: CMTM4

Also called: Chemokine-like factor superfamily member 4CKLF-like MARVEL transmembrane domain-containing protein 4CKLFSF4

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