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Proteins/UNIPROT:P46091
Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Also acts as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity)..
(Microbial infection) Coreceptor for HIV-1..
Function from UniProtKB (P46091), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 statements
3 statements · 2 reference databases · Subject: CMKLR2 · Sources: gene ontology, Hetionet
4 names
Resolves to: CMKLR2