CLMB

Associates with and recruits the catalytic subunit of the calcineurin complex (PPP3CA/Calcineurin A) to the plasma membrane, where it functions as a dynamic scaffold and regulator of PPP3CA activity thereby modulating calcineurin signaling. In brown adipocytes, regulates thermogenesis by binding to PPP3CA, promoting the dephosphorylation of the PKA regulatory subunit, PRKAR2B. This modulation of PRKAR2B phosphorylation enhances PKA activity, thereby stimulating heat thermogenesis (By similarity)..

Function from UniProtKB (Q96GX8), read 2026-09-23. CC BY 4.0.