Proteins/UNIPROT:Q9H2X3

CLEC4M

ProteinUNIPROT:Q9H2X3

Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates..

(Microbial infection) Acts as an attachment receptor for Ebolavirus..

(Microbial infection) Acts as an attachment receptor for Hepatitis C virus..

(Microbial infection) Acts as an attachment receptor for HIV-1..

(Microbial infection) Acts as an attachment receptor for Human coronavirus 229E..

(Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5..

(Microbial infection) Acts as an attachment receptor for Influenzavirus..

(Microbial infection) Acts as an attachment receptor for SARS-CoV..

(Microbial infection) Acts as an attachment receptor for West-nile virus..

(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus..

(Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein..

(Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule..

Function from UniProtKB (Q9H2X3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

12 statements

12 statements · 3 reference databases · Subject: CLEC4M · Sources: Hetionet, Reactome, WikiPathways

Order

CLEC4M interacts with CD209ProteinHetionet hetionet:interacts:10332-30835Inferred only
CEACAM1 interacts with CLEC4MProteinHetionet hetionet:interacts:10332-634Inferred only
ICAM3 interacts with CLEC4MProteinHetionet hetionet:interacts:10332-3385Inferred only
ITGAM interacts with CLEC4MProteinHetionet hetionet:interacts:10332-3684Inferred only
CLEC4M participates in Complement systemPathwayWikiPathways WP2806Inferred only
CLEC4M participates in DiseasePathwayReactome R-HSA-1643685Inferred only
CLEC4M participates in Ebola virus infection in hostPathwayWikiPathways WP4217Inferred only
CLEC4M participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
CLEC4M participates in Measles virus infectionPathwayWikiPathways WP4630Inferred only
CLEC4M participates in Respiratory Syncytial Virus Infection PathwayPathwayReactome R-HSA-9820952Inferred only
CLEC4M participates in RSV-host interactionsPathwayReactome R-HSA-9833110Inferred only
CLEC4M participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only

Other names

11 names

Resolves to: CLEC4M

Also called: CD antigen CD299CD209 antigen-like protein 1CD209LCD209L1CD299DC-SIGN-related proteinDC-SIGN2DC-SIGNRDendritic cell-specific ICAM-3-grabbing non-integrin 2L-SIGNLiver/lymph node-specific ICAM-3-grabbing non-integrin

← Every protein Find it in the graph →