Proteins/UNIPROT:Q8N5K1

CISD2

ProteinUNIPROT:Q8N5K1

Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy..

Function from UniProtKB (Q8N5K1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

Wolfram syndrome has a germline basis in CISD2DiseaseGenCC HGNC:24212|MONDO:0018105Inferred only
Wolfram syndrome 2 has a germline basis in CISD2DiseaseGenCC HGNC:24212|MONDO:0011502Inferred only

Statements

12 statements

12 statements · 3 reference databases · Subject: CISD2 · Sources: gene ontology, Hetionet, UniProt

Order

CISD2 covaries with FBXL22ProteinHetionet hetionet:covaries:283807-493856Inferred only
CISD2 covaries with LHFPL4ProteinHetionet hetionet:covaries:375323-493856Inferred only
CISD2 covaries with RPL13ProteinHetionet hetionet:covaries:493856-6137Inferred only
CISD2 covaries with RPS21ProteinHetionet hetionet:covaries:493856-6227Inferred only
CISD2 covaries with SART1ProteinHetionet hetionet:covaries:493856-9092Inferred only
CISD2 covaries with SCRT2ProteinHetionet hetionet:covaries:493856-85508Inferred only
APP interacts with CISD2ProteinHetionet hetionet:interacts:351-493856Inferred only
BCL2 interacts with CISD2ProteinHetionet hetionet:interacts:493856-596Inferred only
IKBKE interacts with CISD2ProteinHetionet hetionet:interacts:493856-9641Inferred only
UBC interacts with CISD2ProteinHetionet hetionet:interacts:493856-7316Inferred only
CISD2 regulates regulation of autophagyBiological processgene ontology Q8N5K1|GO:0010506Inferred only
CISD2 requires the cofactor di-mu-sulfido-diironCompoundUniProt Q8N5K1Inferred only

Other names

8 names

Resolves to: CISD2

Also called: CDGSH2Endoplasmic reticulum intermembrane small proteinERISMiner1MitoNEET-related 1 proteinNAF-1Nutrient-deprivation autophagy factor-1ZCD2

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