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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q9C0C6

CIPC

Protein·UNIPROT:Q9C0C6

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Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiological relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock..

Function from UniProtKB (Q9C0C6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

9 statements

9 statements · 4 reference databases · Subject: CIPC · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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HOXC12 covaries with CIPCProteinHetionet hetionet:covaries:3228-85457Inferred only
UBL5 covaries with CIPCProteinHetionet hetionet:covaries:59286-85457Inferred only
APPL1 interacts with CIPCProteinHetionet hetionet:interacts:26060-85457Inferred only
COPS5 interacts with CIPCProteinHetionet hetionet:interacts:10987-85457Inferred only
CIPC participates in Circadian clockPathwayReactome R-HSA-9909396Inferred only
CIPC participates in Circadian rhythm genesPathwayWikiPathways WP3594Inferred only
CIPC participates in Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genesPathwayReactome R-HSA-9931510Inferred only
CIPC regulates negative regulation of circadian rhythmBiological processgene ontology Q9C0C6|GO:0042754Inferred only
CIPC regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q9C0C6|GO:0045892Inferred only

Other names

3 names

Resolves to: CIPC

Also called: CLOCK-interacting circadian proteinCLOCK-interacting pacemakerKIAA1737

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