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Proteins/UNIPROT:Q9BU40

CHRDL1

Protein·UNIPROT:Q9BU40

Open in the graph

Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development..

Function from UniProtKB (Q9BU40), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

isolated congenital megalocornea has a germline basis in CHRDL1DiseaseGenCC HGNC:29861|MONDO:0010649Inferred only

Statements

11 statements

11 statements · 3 reference databases · Subject: CHRDL1 · Sources: gene ontology, Hetionet, Reactome

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BMP4 interacts with CHRDL1ProteinHetionet hetionet:interacts:652-91851Inferred only
CHRDL1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
CHRDL1 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
CHRDL1 participates in Post-translational protein phosphorylationPathwayReactome R-HSA-8957275Inferred only
CHRDL1 participates in Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)PathwayReactome R-HSA-381426Inferred only
CHRDL1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CHRDL1 participates in Signaling by BMPPathwayReactome R-HSA-201451Inferred only
CHRDL1 participates in Signaling by TGFB family membersPathwayReactome R-HSA-9006936Inferred only
CHRDL1 regulates negative regulation of BMP signaling pathwayBiological processgene ontology Q9BU40|GO:0030514Inferred only
CCNB2 decreases the expression of CHRDL1ProteinHetionet hetionet:regulates:9133-91851Inferred only
RAB11A decreases the expression of CHRDL1ProteinHetionet hetionet:regulates:8766-91851Inferred only

Other names

4 names

Resolves to: CHRDL1

Also called: Neuralin-1Neurogenesin-1NRLN1Ventroptin

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