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Proteins/UNIPROT:P27918

CFP

Protein·UNIPROT:P27918

Open in the graph

A positive regulator of the alternate pathway (AP) of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b)..

Function from UniProtKB (P27918), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

properdin deficiency, X-linked has a germline basis in CFPDiseaseGenCC HGNC:8864|MONDO:0010713Inferred only

Statements

28 statements

28 statements · 4 reference databases · Subject: CFP · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CFP covaries with ANXA2RProteinHetionet hetionet:covaries:389289-5199Inferred only
C3 interacts with CFPProteinHetionet hetionet:interacts:5199-718Inferred only
CFB interacts with CFPProteinHetionet hetionet:interacts:5199-629Inferred only
MTOR interacts with CFPProteinHetionet hetionet:interacts:2475-5199Inferred only
CFP participates in Activation of C3 and C5PathwayReactome R-HSA-174577Inferred only
CFP participates in Alternative complement activationPathwayReactome R-HSA-173736Inferred only
CFP participates in Complement activationPathwayWikiPathways WP545Inferred only
CFP participates in Complement cascadePathwayReactome R-HSA-166658Inferred only
CFP participates in Complement systemPathwayWikiPathways WP2806Inferred only
CFP participates in Complement system in neuronal development and plasticityPathwayWikiPathways WP5090Inferred only
CFP participates in Defective B3GALTL causes PpSPathwayReactome R-HSA-5083635Inferred only
CFP participates in DiseasePathwayReactome R-HSA-1643685Inferred only

Show the remaining 16

CFP participates in Diseases associated with O-glycosylation of proteinsPathwayReactome R-HSA-3906995Inferred only
CFP participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
CFP participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
CFP participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CFP participates in Initial triggering of complementPathwayReactome R-HSA-166663Inferred only
CFP participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
CFP participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
CFP participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
CFP participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
CFP participates in O-glycosylation of TSR domain-containing proteinsPathwayReactome R-HSA-5173214Inferred only
CFP participates in O-linked glycosylationPathwayReactome R-HSA-5173105Inferred only
CFP participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
CFP participates in Regulation of Complement cascadePathwayReactome R-HSA-977606Inferred only
CFP regulates positive regulation of complement activation, alternative pathwayBiological processgene ontology P27918|GO:0045958Inferred only
CFP regulates positive regulation of immune responseBiological processgene ontology P27918|GO:0050778Inferred only
CFP regulates positive regulation of opsonizationBiological processgene ontology P27918|GO:1903028Inferred only

Other names

3 names

Resolves to: CFP

Also called: Complement factor PPFCProperdin

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