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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q9BXR6

CFHR5

Protein·UNIPROT:Q9BXR6

Open in the graph

Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH..

Function from UniProtKB (Q9BXR6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

C3 glomerulonephritis has a germline basis in CFHR5DiseaseGenCC HGNC:24668|MONDO:0013892Inferred only

Statements

6 statements

6 statements · 3 reference databases · Subject: CFHR5 · Sources: gene ontology, Hetionet, Reactome

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C3 interacts with CFHR5ProteinHetionet hetionet:interacts:718-81494Inferred only
CFHR5 participates in Complement cascadePathwayReactome R-HSA-166658Inferred only
CFHR5 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CFHR5 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
CFHR5 participates in Regulation of Complement cascadePathwayReactome R-HSA-977606Inferred only
CFHR5 regulates positive regulation of complement activationBiological processgene ontology Q9BXR6|GO:0045917Inferred only

Other names

4 names

Resolves to: CFHR5

Also called: CFHL5Complement factor H-related protein 5FHR-5FHR5

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