Proteins/UNIPROT:P36980

CFHR2

ProteinUNIPROT:P36980

Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism..

Function from UniProtKB (P36980), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

6 statements

6 statements · 3 reference databases · Subject: CFHR2 · Sources: gene ontology, Hetionet, Reactome

Order

APP interacts with CFHR2ProteinHetionet hetionet:interacts:3080-351Inferred only
CFHR2 participates in Complement cascadePathwayReactome R-HSA-166658Inferred only
CFHR2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CFHR2 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
CFHR2 participates in Regulation of Complement cascadePathwayReactome R-HSA-977606Inferred only
CFHR2 regulates positive regulation of complement activationBiological processgene ontology P36980|GO:0045917Inferred only

Other names

7 names

Resolves to: CFHR2

Also called: CFHL2DDESK59FHR-2FHR2H factor-like 3H factor-like protein 2HFL3

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