Proteins/UNIPROT:P57076

CFAP298

ProteinUNIPROT:P57076

Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity)..

Function from UniProtKB (P57076), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

primary ciliary dyskinesia has a germline basis in CFAP298DiseaseGenCC HGNC:1301|MONDO:0016575Inferred only
primary ciliary dyskinesia 26 has a germline basis in CFAP298DiseaseGenCC HGNC:1301|MONDO:0014211Inferred only

Statements

14 statements

14 statements · 3 reference databases · Subject: CFAP298 · Sources: gene ontology, Hetionet, WikiPathways

Order

HRAS covaries with CFAP298ProteinHetionet hetionet:covaries:3265-56683Inferred only
APP interacts with CFAP298ProteinHetionet hetionet:interacts:351-56683Inferred only
MAPK6 interacts with CFAP298ProteinHetionet hetionet:interacts:5597-56683Inferred only
SUMO2 interacts with CFAP298ProteinHetionet hetionet:interacts:56683-6613Inferred only
UBC interacts with CFAP298ProteinHetionet hetionet:interacts:56683-7316Inferred only
CFAP298 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
CFAP298 regulates regulation of cilium movementBiological processgene ontology P57076|GO:0003352Inferred only
ASL decreases the expression of CFAP298ProteinHetionet hetionet:regulates:435-56683Inferred only
LRP10 decreases the expression of CFAP298ProteinHetionet hetionet:regulates:26020-56683Inferred only
MYCN increases the expression of CFAP298ProteinHetionet hetionet:regulates:4613-56683Inferred only
RPS14 increases the expression of CFAP298ProteinHetionet hetionet:regulates:6208-56683Inferred only
SMARCB1 decreases the expression of CFAP298ProteinHetionet hetionet:regulates:6598-56683Inferred only

Show the remaining 2

STAT6 increases the expression of CFAP298ProteinHetionet hetionet:regulates:6778-56683Inferred only
SUPV3L1 increases the expression of CFAP298ProteinHetionet hetionet:regulates:6832-56683Inferred only

Other names

5 names

Resolves to: CFAP298

Also called: C21orf48C21orf59Cilia- and flagella-associated protein 298kurly homologProtein kurly homolog

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