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Proteins/UNIPROT:Q8N960

CEP120

Protein·UNIPROT:Q8N960

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Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner..

Function from UniProtKB (Q8N960), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

6 rows

ciliopathy has a germline basis in CEP120DiseaseGenCC HGNC:26690|MONDO:0005308Inferred only
Jeune syndrome has a germline basis in CEP120DiseaseGenCC HGNC:26690|MONDO:0018770Inferred only
Joubert syndrome has a germline basis in CEP120DiseaseGenCC HGNC:26690|MONDO:0018772Inferred only
Joubert syndrome 31 has a germline basis in CEP120DiseaseGenCC HGNC:26690|MONDO:0033310Inferred only
Joubert syndrome with ocular defect has a germline basis in CEP120DiseaseGenCC HGNC:26690|MONDO:0016364Inferred only
short-rib thoracic dysplasia 13 with or without polydactyly has a germline basis in CEP120DiseaseGenCC HGNC:26690|MONDO:0014577Inferred only

Statements

10 statements

10 statements · 3 reference databases · Subject: CEP120 · Sources: gene ontology, Hetionet, WikiPathways

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CEP120 covaries with ZNF554ProteinHetionet hetionet:covaries:115196-153241Inferred only
STAT3 interacts with CEP120ProteinHetionet hetionet:interacts:153241-6774Inferred only
UBC interacts with CEP120ProteinHetionet hetionet:interacts:153241-7316Inferred only
CEP120 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
CEP120 participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only
CEP120 participates in Joubert syndromePathwayWikiPathways WP4656Inferred only
CEP120 regulates positive regulation of centriole elongationBiological processgene ontology Q8N960|GO:1903724Inferred only
CEP120 regulates positive regulation of centrosome duplicationBiological processgene ontology Q8N960|GO:0010825Inferred only
CEP120 regulates positive regulation of cilium assemblyBiological processgene ontology Q8N960|GO:0045724Inferred only
CEP120 regulates positive regulation of establishment of protein localizationBiological processgene ontology Q8N960|GO:1904951Inferred only

Other names

2 names

Resolves to: CEP120

Also called: CCDC100Coiled-coil domain-containing protein 100

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