Proteins/UNIPROT:Q9BWT1

CDCA7

ProteinUNIPROT:Q9BWT1

Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity. Recognizes hemimethylated CpG within nucleosomes where it recruits HELLS to remodel chromatin and facilitate access of de novo DNA methyltransferases to heterochromatic regions, enabling proper establishment of DNA methylation patterns. May play a role as transcriptional regulator..

Function from UniProtKB (Q9BWT1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

immunodeficiency-centromeric instability-facial anomalies syndrome has a germline basis in CDCA7DiseaseGenCC HGNC:14628|MONDO:0000133Inferred only
immunodeficiency-centromeric instability-facial anomalies syndrome 3 has a germline basis in CDCA7DiseaseGenCC HGNC:14628|MONDO:0014828Inferred only

Statements

4 statements

4 statements · 2 reference databases · Subject: CDCA7 · Sources: gene ontology, Hetionet

Order

APP interacts with CDCA7ProteinHetionet hetionet:interacts:351-83879Inferred only
UBC interacts with CDCA7ProteinHetionet hetionet:interacts:7316-83879Inferred only
CDCA7 regulates regulation of cell population proliferationBiological processgene ontology Q9BWT1|GO:0042127Inferred only
CDCA7 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q9BWT1|GO:0006355Inferred only

Other names

3 names

Resolves to: CDCA7

Also called: Cell division cycle-associated protein 7JPO1Protein JPO1

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