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Proteins/UNIPROT:Q8TD46

CD200R1

Protein·UNIPROT:Q8TD46

Open in the graph

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200..

Function from UniProtKB (Q8TD46), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

11 statements

11 statements · 3 reference databases · Subject: CD200R1 · Sources: gene ontology, Hetionet, Reactome

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CD200R1 covaries with C2CD4BProteinHetionet hetionet:covaries:131450-388125Inferred only
CD200R1 covaries with SLCO1B1ProteinHetionet hetionet:covaries:10599-131450Inferred only
CD200 interacts with CD200R1ProteinHetionet hetionet:interacts:131450-4345Inferred only
CD200R1 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
CD200R1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CD200R1 participates in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellPathwayReactome R-HSA-198933Inferred only
CD200R1 regulates negative regulation of interleukin-6 productionBiological processgene ontology Q8TD46|GO:0032715Inferred only
CD200R1 regulates negative regulation of macrophage migrationBiological processgene ontology Q8TD46|GO:1905522Inferred only
CD200R1 regulates negative regulation of neuroinflammatory responseBiological processgene ontology Q8TD46|GO:0150079Inferred only
CD200R1 regulates negative regulation of T cell migrationBiological processgene ontology Q8TD46|GO:2000405Inferred only
CD200R1 regulates regulation of neuroinflammatory responseBiological processgene ontology Q8TD46|GO:0150077Inferred only

Other names

6 names

Resolves to: CD200R1

Also called: CD200 cell surface glycoprotein receptorCD200RCell surface glycoprotein OX2 receptor 1CRTR2MOX2ROX2R

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