Proteins/UNIPROT:Q9BSQ5

CCM2

ProteinUNIPROT:Q9BSQ5

Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity)..

Function from UniProtKB (Q9BSQ5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

cerebral cavernous malformation 2 has a germline basis in CCM2DiseaseGenCC HGNC:21708|MONDO:0011304Inferred only
famililal cerebral cavernous malformations has a germline basis in CCM2DiseaseGenCC HGNC:21708|MONDO:0031037Inferred only

Statements

7 statements

7 statements · 2 reference databases · Subject: CCM2 · Sources: gene ontology, Hetionet

Order

KRIT1 interacts with CCM2ProteinHetionet hetionet:interacts:83605-889Inferred only
PDCD10 interacts with CCM2ProteinHetionet hetionet:interacts:11235-83605Inferred only
SMURF1 interacts with CCM2ProteinHetionet hetionet:interacts:57154-83605Inferred only
SMURF2 interacts with CCM2ProteinHetionet hetionet:interacts:64750-83605Inferred only
SRPK2 interacts with CCM2ProteinHetionet hetionet:interacts:6733-83605Inferred only
STK25 interacts with CCM2ProteinHetionet hetionet:interacts:10494-83605Inferred only
CCM2 regulates regulation of angiogenesisBiological processgene ontology Q9BSQ5|GO:0045765Inferred only

Other names

3 names

Resolves to: CCM2

Also called: C7orf22Cerebral cavernous malformations 2 proteinMalcavernin

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