Proteins/UNIPROT:P32238

CCKAR

ProteinUNIPROT:P32238

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Function from UniProtKB (P32238), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 4 reference databases · Subject: CCKAR · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CCKAR covaries with APOL6ProteinHetionet hetionet:covaries:80830-886Inferred only
CCKAR covaries with FAM186AProteinHetionet hetionet:covaries:121006-886Inferred only
CCKAR covaries with MFIProteinHetionet hetionet:covaries:160140-886Inferred only
CCKAR covaries with PCSK9ProteinHetionet hetionet:covaries:255738-886Inferred only
CCKAR covaries with SAMD15ProteinHetionet hetionet:covaries:161394-886Inferred only
CCKAR covaries with TFF2ProteinHetionet hetionet:covaries:7032-886Inferred only
CCK interacts with CCKARProteinHetionet hetionet:interacts:885-886Inferred only
CCKAR interacts with PPP1R9BProteinHetionet hetionet:interacts:84687-886Inferred only
CCKAR participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
CCKAR participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
CCKAR participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
CCKAR participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only

Show the remaining 6

CCKAR participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
CCKAR participates in Peptide GPCRsPathwayWikiPathways WP24Inferred only
CCKAR participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
CCKAR participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CCKAR participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
CCKAR regulates regulation of hormone secretionBiological processgene ontology P32238|GO:0046883Inferred only

Other names

5 names

Resolves to: CCKAR

Also called: CCK-A receptorCCK-ARCCK1-RCCKRACholecystokinin-1 receptor

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