Proteins/UNIPROT:Q9H0W5

CCDC8

ProteinUNIPROT:Q9H0W5

Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome..

Function from UniProtKB (Q9H0W5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

3-M syndrome has a germline basis in CCDC8DiseaseGenCC HGNC:25367|MONDO:0007477Inferred only
3M syndrome 3 has a germline basis in CCDC8DiseaseGenCC HGNC:25367|MONDO:0013627Inferred only

Statements

12 statements

12 statements · 3 reference databases · Subject: CCDC8 · Sources: gene ontology, Hetionet, Reactome

Order

CPXCR1 covaries with CCDC8ProteinHetionet hetionet:covaries:53336-83987Inferred only
F2RL2 covaries with CCDC8ProteinHetionet hetionet:covaries:2151-83987Inferred only
NREP covaries with CCDC8ProteinHetionet hetionet:covaries:83987-9315Inferred only
CCDC8 covaries with PGLSProteinHetionet hetionet:covaries:25796-83987Inferred only
CCDC8 covaries with ZNF684ProteinHetionet hetionet:covaries:127396-83987Inferred only
PPP1CA interacts with CCDC8ProteinHetionet hetionet:interacts:5499-83987Inferred only
TP53 interacts with CCDC8ProteinHetionet hetionet:interacts:7157-83987Inferred only
UBC interacts with CCDC8ProteinHetionet hetionet:interacts:7316-83987Inferred only
CCDC8 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
CCDC8 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
CCDC8 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
CCDC8 regulates regulation of mitotic nuclear divisionBiological processgene ontology Q9H0W5|GO:0007088Inferred only

Other names

1 name

Resolves to: CCDC8

Also called: Coiled-coil domain-containing protein 8

← Every protein Find it in the graph →