CCDC66

Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites. Required for the assembly of signaling-competent cilia with proper structure and length. Mediates this function in part by regulating transition zone assembly and basal body recruitment of the IFT-B complex. Cooperates with the ciliopathy proteins CSPP1 and CEP104 during cilium length regulation. Essential for cilium elongation, maintaining ciliary length and stability, and inhibiting disassembly (likely by stabilizing the axoneme) (By similarity). Also plays a role in ciliary Hedgehog pathway activation (By similarity). Plays two important roles during cell division. First, is required for mitotic progression via regulation of spindle assembly, organization and orientation, levels of spindle microtubules (MTs), kinetochore-fiber integrity, and chromosome alignment. Second, functions during cytokinesis in part by regulating assembly and organization of central spindle and midbody MTs. Plays a role in retina morphogenesis and/or homeostasis (By similarity)..

Function from UniProtKB (A2RUB6), read 2026-09-23. CC BY 4.0.