Proteins/UNIPROT:Q9UFE4

CCDC39

ProteinUNIPROT:Q9UFE4

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly..

Function from UniProtKB (Q9UFE4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

primary ciliary dyskinesia has a germline basis in CCDC39DiseaseGenCC HGNC:25244|MONDO:0016575Inferred only
primary ciliary dyskinesia 14 has a germline basis in CCDC39DiseaseGenCC HGNC:25244|MONDO:0013434Inferred only

Statements

9 statements

9 statements · 3 reference databases · Subject: CCDC39 · Sources: gene ontology, Hetionet, WikiPathways

Order

CCDC175 covaries with CCDC39ProteinHetionet hetionet:covaries:339829-729665Inferred only
CCDC39 covaries with CFAP43ProteinHetionet hetionet:covaries:339829-80217Inferred only
CCDC39 covaries with HYDINProteinHetionet hetionet:covaries:339829-54768Inferred only
CCDC39 covaries with RGS22ProteinHetionet hetionet:covaries:26166-339829Inferred only
CCDC39 covaries with SPEF2ProteinHetionet hetionet:covaries:339829-79925Inferred only
CCDC39 covaries with TRIM52ProteinHetionet hetionet:covaries:339829-84851Inferred only
CUL3 interacts with CCDC39ProteinHetionet hetionet:interacts:339829-8452Inferred only
CCDC39 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
CCDC39 regulates regulation of cilium beat frequencyBiological processgene ontology Q9UFE4|GO:0003356Inferred only

Other names

1 name

Resolves to: CCDC39

Also called: Coiled-coil domain-containing protein 39

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