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Proteins/UNIPROT:Q8WTX7
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway..
Function from UniProtKB (Q8WTX7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
6 statements
6 statements · 2 reference databases · Subject: CASTOR1 · Sources: gene ontology, Reactome
3 names
Resolves to: CASTOR1