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Proteins/UNIPROT:P31415
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity..
Function from UniProtKB (P31415), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
10 statements
10 statements · 2 reference databases · Subject: CASQ1 · Sources: gene ontology, Reactome
3 names
Resolves to: CASQ1