Proteins/UNIPROT:Q6UXS9

CASP12

ProteinUNIPROT:Q6UXS9

May function as a negative regulator of inflammatory responses and innate immunity. May reduce cytokine release in response to bacterial lipopolysaccharide during infection. Reduces activation of NF-kappa-B in response to TNF. May lack protease activity (Probable)..

Function from UniProtKB (Q6UXS9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 3 reference databases · Subject: CASP12 · Sources: gene ontology, Hetionet, WikiPathways

Order

LIPT2 covaries with CASP12ProteinHetionet hetionet:covaries:100506742-387787Inferred only
CASP12 covaries with PARS2ProteinHetionet hetionet:covaries:100506742-25973Inferred only
NOD2 interacts with CASP12ProteinHetionet hetionet:interacts:100506742-64127Inferred only
RIPK2 interacts with CASP12ProteinHetionet hetionet:interacts:100506742-8767Inferred only
TRAF2 interacts with CASP12ProteinHetionet hetionet:interacts:100506742-7186Inferred only
UBC interacts with CASP12ProteinHetionet hetionet:interacts:100506742-7316Inferred only
UBE2K interacts with CASP12ProteinHetionet hetionet:interacts:100506742-3093Inferred only
CASP12 participates in Alzheimer 39 s diseasePathwayWikiPathways WP5124Inferred only
CASP12 participates in Alzheimer 39 s disease and miRNA effectsPathwayWikiPathways WP2059Inferred only
CASP12 participates in Amyotrophic lateral sclerosis ALS PathwayWikiPathways WP2447Inferred only
CASP12 participates in Corticotropin releasing hormone signalingPathwayWikiPathways WP2355Inferred only
CASP12 participates in Hepatitis B infectionPathwayWikiPathways WP4666Inferred only

Show the remaining 3

CASP12 participates in Prion disease pathwayPathwayWikiPathways WP3995Inferred only
CASP12 regulates positive regulation of inflammatory responseBiological processgene ontology Q6UXS9|GO:0050729Inferred only
CASP12 regulates positive regulation of neuron apoptotic processBiological processgene ontology Q6UXS9|GO:0043525Inferred only

Other names

2 names

Resolves to: CASP12

Also called: CASP-12Inactive caspase-12

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