Proteins/UNIPROT:Q8N3J6

CADM2

ProteinUNIPROT:Q8N3J6

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes..

[Isoform 5]: (Microbial infection) Induces cell fusion in neuron infected by a neuropathogenic strain of measles. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus..

Function from UniProtKB (Q8N3J6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

6 statements

6 statements · 3 reference databases · Subject: CADM2 · Sources: Hetionet, Reactome, WikiPathways

Order

CADM2 covaries with TERB2ProteinHetionet hetionet:covaries:145645-253559Inferred only
CADM2 participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
CADM2 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
CADM2 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
CADM2 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
CADM2 participates in Fumarate hydratase deficient papillary renal cell carcinomaPathwayWikiPathways WP4241Inferred only

Other names

7 names

Resolves to: CADM2

Also called: IGSF4DImmunoglobulin superfamily member 4DNECL-3NECL3Nectin-like protein 3Synaptic cell adhesion molecule 2SynCAM 2

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