Proteins/UNIPROT:Q9NZ63

C9orf78

ProteinUNIPROT:Q9NZ63

Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides. May also modulate exon inclusion events. Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity. Binds U5 snRNA. Required for proper chromosome segregation. Not required for splicing of shelterin components..

Function from UniProtKB (Q9NZ63), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

21 statements

21 statements · 3 reference databases · Subject: C9orf78 · Sources: gene ontology, Hetionet, Reactome

Order

C9orf78 covaries with FXYD7ProteinHetionet hetionet:covaries:51759-53822Inferred only
KLLN covaries with C9orf78ProteinHetionet hetionet:covaries:100144748-51759Inferred only
OR52M1 covaries with C9orf78ProteinHetionet hetionet:covaries:119772-51759Inferred only
C9orf78 covaries with ZNF10ProteinHetionet hetionet:covaries:51759-7556Inferred only
C9orf78 covaries with ZNF197ProteinHetionet hetionet:covaries:10168-51759Inferred only
C9orf78 covaries with ZNF26ProteinHetionet hetionet:covaries:51759-7574Inferred only
C9orf78 covaries with ZNF570ProteinHetionet hetionet:covaries:148268-51759Inferred only
APP interacts with C9orf78ProteinHetionet hetionet:interacts:351-51759Inferred only
FCHSD2 interacts with C9orf78ProteinHetionet hetionet:interacts:51759-9873Inferred only
MAPK11 interacts with C9orf78ProteinHetionet hetionet:interacts:51759-5600Inferred only
SUPT5H interacts with C9orf78ProteinHetionet hetionet:interacts:51759-6829Inferred only
TAB1 interacts with C9orf78ProteinHetionet hetionet:interacts:10454-51759Inferred only

Show the remaining 9

C9orf78 interacts with TERF2IPProteinHetionet hetionet:interacts:51759-54386Inferred only
UBC interacts with C9orf78ProteinHetionet hetionet:interacts:51759-7316Inferred only
C9orf78 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
C9orf78 participates in mRNA SplicingPathwayReactome R-HSA-72172Inferred only
C9orf78 participates in mRNA Splicing - Major PathwayPathwayReactome R-HSA-72163Inferred only
C9orf78 participates in Processing of Capped Intron-Containing Pre-mRNAPathwayReactome R-HSA-72203Inferred only
C9orf78 regulates regulation of homologous chromosome segregationBiological processgene ontology Q9NZ63|GO:0060629Inferred only
ANXA7 decreases the expression of C9orf78ProteinHetionet hetionet:regulates:310-51759Inferred only
CEBPG increases the expression of C9orf78ProteinHetionet hetionet:regulates:1054-51759Inferred only

Other names

3 names

Resolves to: C9orf78

Also called: HCA59Hepatocellular carcinoma-associated antigen 59Splicing factor C9orf78

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