Proteins/UNIPROT:Q6P5X5

C22orf39

ProteinUNIPROT:Q6P5X5

Negatively regulates long-term potentiation and modulates adult synaptic plasticity. Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites. Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses..

Function from UniProtKB (Q6P5X5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

4 statements

4 statements · 3 reference databases · Subject: C22orf39 · Sources: gene ontology, Hetionet, WikiPathways

Order

PPP2CB interacts with C22orf39ProteinHetionet hetionet:interacts:128977-5516Inferred only
C22orf39 participates in 22q11 2 copy number variation syndromePathwayWikiPathways WP4657Inferred only
C22orf39 regulates negative regulation of long-term synaptic potentiationBiological processgene ontology Q6P5X5|GO:1900272Inferred only
C22orf39 regulates regulation of synaptic plasticityBiological processgene ontology Q6P5X5|GO:0048167Inferred only

Other names

2 names

Resolves to: C22orf39

Also called: Plasticity-associated neural transcript shortSynaptic plasticity regulator PANTS

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