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Proteins/UNIPROT:Q7Z6A9

BTLA

Protein·UNIPROT:Q7Z6A9

Open in the graph

Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells..

Function from UniProtKB (Q7Z6A9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

17 statements

17 statements · 4 reference databases · Subject: BTLA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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PTPN11 interacts with BTLAProteinHetionet hetionet:interacts:151888-5781Inferred only
PTPN6 interacts with BTLAProteinHetionet hetionet:interacts:151888-5777Inferred only
TNFRSF14 interacts with BTLAProteinHetionet hetionet:interacts:151888-8764Inferred only
VTCN1 interacts with BTLAProteinHetionet hetionet:interacts:151888-79679Inferred only
BTLA participates in 1p36 copy number variation syndromePathwayWikiPathways WP5345Inferred only
BTLA participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
BTLA participates in Co-inhibition by BTLAPathwayReactome R-HSA-9927353Inferred only
BTLA participates in Extrafollicular and follicular B cell activation by SARS CoV 2PathwayWikiPathways WP5218Inferred only
BTLA participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
BTLA participates in Regulation of T cell activation by CD28 familyPathwayReactome R-HSA-388841Inferred only
BTLA participates in Vitamin D receptor pathwayPathwayWikiPathways WP2877Inferred only
BTLA regulates negative regulation of T cell activationBiological processgene ontology Q7Z6A9|GO:0050868Inferred only

Show the remaining 5

BTLA regulates negative regulation of T cell cytokine productionBiological processgene ontology Q7Z6A9|GO:0002725Inferred only
BTLA regulates negative regulation of T cell proliferationBiological processgene ontology Q7Z6A9|GO:0042130Inferred only
BTLA regulates regulation of B cell proliferationBiological processgene ontology Q7Z6A9|GO:0030888Inferred only
BTLA regulates regulation of ERK1 and ERK2 cascadeBiological processgene ontology Q7Z6A9|GO:0070372Inferred only
BTLA regulates regulation of T cell tolerance induction to tumor cellBiological processgene ontology Q7Z6A9|GO:0002846Inferred only

Other names

2 names

Resolves to: BTLA

Also called: B- and T-lymphocyte-associated proteinCD antigen CD272

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