Proteins/UNIPROT:Q8TDH9

BLOC1S5

ProteinUNIPROT:Q8TDH9

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking..

Function from UniProtKB (Q8TDH9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

Hermansky-Pudlak syndrome has a germline basis in BLOC1S5DiseaseGenCC HGNC:18561|MONDO:0019312Inferred only
Hermansky-Pudlak syndrome 11 has a germline basis in BLOC1S5DiseaseGenCC HGNC:18561|MONDO:0030903Inferred only

Statements

8 statements

8 statements · 2 reference databases · Subject: BLOC1S5 · Sources: gene ontology, Hetionet

Order

APP interacts with BLOC1S5ProteinHetionet hetionet:interacts:351-63915Inferred only
BLOC1S5 interacts with BLOC1S2ProteinHetionet hetionet:interacts:282991-63915Inferred only
BLOC1S4 interacts with BLOC1S5ProteinHetionet hetionet:interacts:55330-63915Inferred only
BLOC1S6 interacts with BLOC1S5ProteinHetionet hetionet:interacts:26258-63915Inferred only
DCUN1D1 interacts with BLOC1S5ProteinHetionet hetionet:interacts:54165-63915Inferred only
BLOC1S5 interacts with DTNBP1ProteinHetionet hetionet:interacts:63915-84062Inferred only
SNAPIN interacts with BLOC1S5ProteinHetionet hetionet:interacts:23557-63915Inferred only
BLOC1S5 regulates positive regulation of pigment cell differentiationBiological processgene ontology Q8TDH9|GO:0050942Inferred only

Other names

4 names

Resolves to: BLOC1S5

Also called: BLOC-1 subunit 5MUTEDMuted homologProtein Muted homolog

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