Proteins/UNIPROT:Q86UU0

BCL9L

ProteinUNIPROT:Q86UU0

Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity)..

Function from UniProtKB (Q86UU0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

visceral heterotaxy has a germline basis in BCL9LDiseaseGenCC HGNC:23688|MONDO:0018677Inferred only

Statements

14 statements

14 statements · 3 reference databases · Subject: BCL9L · Sources: gene ontology, Hetionet, Reactome

Order

CRHR1 covaries with BCL9LProteinHetionet hetionet:covaries:1394-283149Inferred only
CDC73 interacts with BCL9LProteinHetionet hetionet:interacts:283149-79577Inferred only
CTNNB1 interacts with BCL9LProteinHetionet hetionet:interacts:1499-283149Inferred only
EGR1 interacts with BCL9LProteinHetionet hetionet:interacts:1958-283149Inferred only
BCL9L participates in Deactivation of the beta-catenin transactivating complexPathwayReactome R-HSA-3769402Inferred only
BCL9L participates in Formation of the beta-catenin:TCF transactivating complexPathwayReactome R-HSA-201722Inferred only
BCL9L participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
BCL9L participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
BCL9L participates in TCF dependent signaling in response to WNTPathwayReactome R-HSA-201681Inferred only
BCL9L regulates negative regulation of transforming growth factor beta receptor signaling pathwayBiological processgene ontology Q86UU0|GO:0030512Inferred only
BCL9L regulates positive regulation of epithelial to mesenchymal transitionBiological processgene ontology Q86UU0|GO:0010718Inferred only
BCL9L regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q86UU0|GO:0045944Inferred only

Show the remaining 2

BCL9L regulates regulation of cell morphogenesisBiological processgene ontology Q86UU0|GO:0022604Inferred only
BCL9L decreases the expression of ENOPH1ProteinHetionet hetionet:regulates:283149-58478Inferred only

Other names

5 names

Resolves to: BCL9L

Also called: B-cell lymphoma 9-like proteinBCL9-2BCL9-like proteinDLNB11Protein BCL9-2

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