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Proteins/UNIPROT:Q9H165
Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development. May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity)..
Function from UniProtKB (Q9H165), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
45 statements
45 statements · 4 reference databases · Subject: BCL11A · Sources: gene ontology, Hetionet, Reactome, WikiPathways
11 names
Resolves to: BCL11A