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Proteins/UNIPROT:Q2TB18
Structure-specific DNA endonuclease that specifically cleaves single-stranded DNA and 3' overhang DNA. Contributes to the control of DNA double-strand break repair choice by antagonizing BRCA1-dependent homologous recombination (HR) and promoting non-homologous end-joining (NHEJ). Recruited to the single-stranded DNA ends by SHLD2 and cleaves the 3' exposed DNA ends, therefore inhibiting DNA end resection (necessary for HR) and promoting DNA end protection (necessary for NHEJ)..
Function from UniProtKB (Q2TB18), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 statements
4 statements · 1 reference database · Subject: ASTE1 · Sources: Hetionet
2 names
Resolves to: ASTE1