Proteins/UNIPROT:Q9Y575

ASB3

ProteinUNIPROT:Q9Y575

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. Plays a role in the down-regulation of antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation. Also destabilizes TRAF6 by enhancing its 'Lys-48'-linked polyubiquitination..

Function from UniProtKB (Q9Y575), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 2 reference databases · Subject: ASB3 · Sources: Hetionet, Reactome

Order

ASB3 covaries with ZNF554ProteinHetionet hetionet:covaries:115196-51130Inferred only
CUL5 interacts with ASB3ProteinHetionet hetionet:interacts:100302652-8065Inferred only
DCUN1D1 interacts with ASB3ProteinHetionet hetionet:interacts:100302652-54165Inferred only
ELOC interacts with ASB3ProteinHetionet hetionet:interacts:51130-6921Inferred only
HSP90AA1 interacts with ASB3ProteinHetionet hetionet:interacts:100302652-3320Inferred only
HSP90AB1 interacts with ASB3ProteinHetionet hetionet:interacts:3326-51130Inferred only
ZAP70 interacts with ASB3ProteinHetionet hetionet:interacts:100302652-7535Inferred only
ZAP70 interacts with ASB3ProteinHetionet hetionet:interacts:51130-7535Inferred only
ASB3 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
ASB3 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
ASB3 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
ASB3 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only

Show the remaining 3

ASB3 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ASB3 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
ASB3 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Other names

2 names

Resolves to: ASB3

Also called: Ankyrin repeat and SOCS box protein 3ASB-3

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