Proteins/UNIPROT:Q8WXH4

ASB11

ProteinUNIPROT:Q8WXH4

Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as BIK, DIRAS2 and RPN1. The ECS(ASB11) complex acts as a regulator of the endoplasmic reticulum unfolded protein response by mediating ubiquitination and degradation of BIK..

Function from UniProtKB (Q8WXH4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 3 reference databases · Subject: ASB11 · Sources: gene ontology, Hetionet, Reactome

Order

ASB11 covaries with SSC5DProteinHetionet hetionet:covaries:140456-284297Inferred only
ZNF157 covaries with ASB11ProteinHetionet hetionet:covaries:140456-7712Inferred only
ASB11 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
ASB11 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
ASB11 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
ASB11 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
ASB11 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ASB11 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
ASB11 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ASB11 regulates positive regulation of protein catabolic processBiological processgene ontology Q8WXH4|GO:0045732Inferred only

Other names

2 names

Resolves to: ASB11

Also called: Ankyrin repeat and SOCS box protein 11ASB-11

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