ASB1

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Mediates Notch-induced ubiquitination and degradation of TCF3/E2A and JAK2. Functions as a tumor suppressor by enhancing CHCHD3 'Lys-48'-linked ubiquitination, leading to inhibition of the CHCHD3/ROS signaling pathway. Suppresses TAB2-linked 'Lys-48' polyubiquitination and consequently facilitates the initiation of NF-kappa-B and MAPK signaling cascades. May play a role in testis development (By similarity)..

Function from UniProtKB (Q9Y576), read 2026-09-23. CC BY 4.0.