Proteins/UNIPROT:Q7Z6K5

ARPIN

ProteinUNIPROT:Q7Z6K5

Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence..

Function from UniProtKB (Q7Z6K5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

4 statements

4 statements · 2 reference databases · Subject: ARPIN · Sources: gene ontology, Hetionet

Order

UBC interacts with ARPINProteinHetionet hetionet:interacts:348110-7316Inferred only
ARPIN regulates negative regulation of actin nucleationBiological processgene ontology Q7Z6K5|GO:0051126Inferred only
ARPIN regulates negative regulation of cell migrationBiological processgene ontology Q7Z6K5|GO:0030336Inferred only
ARPIN regulates negative regulation of lamellipodium morphogenesisBiological processgene ontology Q7Z6K5|GO:2000393Inferred only

Other names

2 names

Resolves to: ARPIN

Also called: Arp2/3 inhibition proteinC15orf38

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