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Proteins/UNIPROT:Q96Q42

ALS2

Protein·UNIPROT:Q96Q42

Open in the graph

May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity)..

Function from UniProtKB (Q96Q42), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

5 rows

ALS2-related motor neuron disease has a germline basis in ALS2DiseaseGenCC HGNC:443|MONDO:0100227Inferred only
amyotrophic lateral sclerosis type 2, juvenile has a germline basis in ALS2DiseaseGenCC HGNC:443|MONDO:0008780Inferred only
infantile-onset ascending hereditary spastic paralysis has a germline basis in ALS2DiseaseGenCC HGNC:443|MONDO:0011797Inferred only
juvenile amyotrophic lateral sclerosis has a germline basis in ALS2DiseaseGenCC HGNC:443|MONDO:0017593Inferred only
juvenile primary lateral sclerosis has a germline basis in ALS2DiseaseGenCC HGNC:443|MONDO:0011663Inferred only

Statements

25 statements

25 statements · 4 reference databases · Subject: ALS2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ALS2 covaries with FAM171A2ProteinHetionet hetionet:covaries:284069-57679Inferred only
ALS2 covaries with NPBProteinHetionet hetionet:covaries:256933-57679Inferred only
ALS2 covaries with RTN1ProteinHetionet hetionet:covaries:57679-6252Inferred only
CREB1 interacts with ALS2ProteinHetionet hetionet:interacts:1385-57679Inferred only
LYL1 interacts with ALS2ProteinHetionet hetionet:interacts:4066-57679Inferred only
RAB5A interacts with ALS2ProteinHetionet hetionet:interacts:57679-5868Inferred only
RAC1 interacts with ALS2ProteinHetionet hetionet:interacts:57679-5879Inferred only
UBC interacts with ALS2ProteinHetionet hetionet:interacts:57679-7316Inferred only
VCP interacts with ALS2ProteinHetionet hetionet:interacts:57679-7415Inferred only
YWHAB interacts with ALS2ProteinHetionet hetionet:interacts:57679-7529Inferred only
ALS2 participates in Amyotrophic lateral sclerosis ALS PathwayWikiPathways WP2447Inferred only
ALS2 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only

Show the remaining 13

ALS2 participates in RAB GEFs exchange GTP for GDP on RABsPathwayReactome R-HSA-8876198Inferred only
ALS2 participates in Rab regulation of traffickingPathwayReactome R-HSA-9007101Inferred only
ALS2 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
ALS2 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
ALS2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ALS2 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
ALS2 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ALS2 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
ALS2 regulates positive regulation of GTPase activityBiological processgene ontology Q96Q42|GO:0043547Inferred only
ALS2 regulates positive regulation of protein kinase activityBiological processgene ontology Q96Q42|GO:0045860Inferred only
ALS2 regulates positive regulation of Rac protein signal transductionBiological processgene ontology Q96Q42|GO:0035022Inferred only
ALS2 regulates regulation of endosome sizeBiological processgene ontology Q96Q42|GO:0051036Inferred only
ALS2 regulates regulation of postsynaptic membrane neurotransmitter receptor levelsBiological processgene ontology Q96Q42|GO:0099072Inferred only

Other names

4 names

Resolves to: ALS2

Also called: ALS2CR6Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 proteinAmyotrophic lateral sclerosis 2 proteinKIAA1563

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