Proteins/UNIPROT:Q8IUX7

AEBP1

ProteinUNIPROT:Q8IUX7

[Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix..

[Isoform 2]: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor..

Function from UniProtKB (Q8IUX7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Ehlers-Danlos syndrome, classic-like, 2 has a germline basis in AEBP1DiseaseGenCC HGNC:303|MONDO:0054813Inferred only

Statements

6 statements

6 statements · 2 reference databases · Subject: AEBP1 · Sources: gene ontology, Hetionet

Order

NACAD covaries with AEBP1ProteinHetionet hetionet:covaries:165-23148Inferred only
AEBP1 interacts with GRB2ProteinHetionet hetionet:interacts:165-2885Inferred only
AEBP1 interacts with TCF3ProteinHetionet hetionet:interacts:165-6929Inferred only
AEBP1 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q8IUX7|GO:0000122Inferred only
AEBP1 regulates regulation of collagen fibril organizationBiological processgene ontology Q8IUX7|GO:1904026Inferred only
AEBP1 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q8IUX7|GO:0006355Inferred only

Other names

3 names

Resolves to: AEBP1

Also called: ACLPAE-binding protein 1Aortic carboxypeptidase-like protein

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