ADAMTS20

Cleaves peptide bond of the large aggregating proteoglycan, versican (at the '1428-Glu-|-Ala-1429' site) (By similarity). In addition, catalyzes the shedding of the endopeptidase MMP14 (at the '314-Tyr-|-Gly-315' site), releasing the catalytic domain from the cell surface thereby preventing the downstream pro-MMP2 activation (By similarity). Is involved in extracellular matrix proteolysis and ciliogenesis (By similarity). May have a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos (By similarity)..

Function from UniProtKB (P59510), read 2026-09-23. CC BY 4.0.