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Proteins/UNIPROT:Q8TE58

ADAMTS15

Protein·UNIPROT:Q8TE58

Open in the graph

Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration..

Function from UniProtKB (Q8TE58), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

arthrogryposis, distal, type 12 has a germline basis in ADAMTS15DiseaseGenCC HGNC:16305|MONDO:0957819Inferred only

Statements

11 statements

11 statements · 3 reference databases · Subject: ADAMTS15 · Sources: Hetionet, Reactome, UniProt

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ADAMTS15 covaries with C2CD4BProteinHetionet hetionet:covaries:170689-388125Inferred only
ADAMTS15 participates in Defective B3GALTL causes PpSPathwayReactome R-HSA-5083635Inferred only
ADAMTS15 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
ADAMTS15 participates in Diseases associated with O-glycosylation of proteinsPathwayReactome R-HSA-3906995Inferred only
ADAMTS15 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
ADAMTS15 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
ADAMTS15 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ADAMTS15 participates in O-glycosylation of TSR domain-containing proteinsPathwayReactome R-HSA-5173214Inferred only
ADAMTS15 participates in O-linked glycosylationPathwayReactome R-HSA-5173105Inferred only
ADAMTS15 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ADAMTS15 requires the cofactor Zn(2+)CompoundUniProt Q8TE58Inferred only

Other names

3 names

Resolves to: ADAMTS15

Also called: ADAM-TS 15ADAM-TS15ADAMTS-15

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