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Proteins/UNIPROT:P58397

ADAMTS12

Protein·UNIPROT:P58397

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Metalloprotease that may play a role in the degradation of COMP. Also cleaves alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties..

Function from UniProtKB (P58397), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

18 statements

18 statements · 4 reference databases · Subject: ADAMTS12 · Sources: gene ontology, Hetionet, Reactome, UniProt

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EDN2 covaries with ADAMTS12ProteinHetionet hetionet:covaries:1907-81792Inferred only
ADAMTS12 covaries with PDZD2ProteinHetionet hetionet:covaries:23037-81792Inferred only
ADAMTS12 participates in Defective B3GALTL causes PpSPathwayReactome R-HSA-5083635Inferred only
ADAMTS12 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
ADAMTS12 participates in Diseases associated with O-glycosylation of proteinsPathwayReactome R-HSA-3906995Inferred only
ADAMTS12 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
ADAMTS12 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
ADAMTS12 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ADAMTS12 participates in O-glycosylation of TSR domain-containing proteinsPathwayReactome R-HSA-5173214Inferred only
ADAMTS12 participates in O-linked glycosylationPathwayReactome R-HSA-5173105Inferred only
ADAMTS12 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ADAMTS12 regulates negative regulation of cellular response to hepatocyte growth factor stimulusBiological processgene ontology P58397|GO:2001113Inferred only

Show the remaining 6

ADAMTS12 regulates negative regulation of cellular response to vascular endothelial growth factor stimulusBiological processgene ontology P58397|GO:1902548Inferred only
ADAMTS12 regulates negative regulation of chondrocyte differentiationBiological processgene ontology P58397|GO:0032331Inferred only
ADAMTS12 regulates negative regulation of hepatocyte growth factor receptor signaling pathwayBiological processgene ontology P58397|GO:1902203Inferred only
ADAMTS12 regulates regulation of endothelial tube morphogenesisBiological processgene ontology P58397|GO:1901509Inferred only
ADAMTS12 regulates regulation of inflammatory responseBiological processgene ontology P58397|GO:0050727Inferred only
ADAMTS12 requires the cofactor Zn(2+)CompoundUniProt P58397Inferred only

Other names

3 names

Resolves to: ADAMTS12

Also called: ADAM-TS 12ADAM-TS12ADAMTS-12

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